PPP1CB

PPP1CB
Identifiers
Aliases	PPP1CB, HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, protein phosphatase 1 catalytic subunit beta
External IDs	MGI: 104871 HomoloGene: 37659 GeneCards: PPP1CB
Gene ontology Molecular function • phosphoprotein phosphatase activity • myosin phosphatase activity • phosphatase activity • protein serine/threonine phosphatase activity • metal ion binding • myosin-light-chain-phosphatase activity • protein binding • protein kinase binding • hydrolase activity Cellular component • cytoplasm • cytosol • focal adhesion • nucleoplasm • protein phosphatase type 1 complex • glycogen granule • PTW/PP1 phosphatase complex • nucleolus • extracellular exosome • nucleus • nuclear chromosome, telomeric region Biological process • carbohydrate metabolic process • rhythmic process • protein dephosphorylation • circadian regulation of gene expression • cell division • regulation of cell adhesion • G2/M transition of mitotic cell cycle • regulation of circadian rhythm • glycogen metabolic process • regulation of glycogen biosynthetic process • cell cycle • regulation of glycogen catabolic process • entrainment of circadian clock by photoperiod Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5500	19046
Ensembl	ENSG00000213639	ENSMUSG00000014956
UniProt	P62140	P62141
RefSeq (mRNA)	NM_206877 NM_002709 NM_206876	NM_172707
RefSeq (protein)	NP_002700 NP_996759	NP_766295.2 NP_766295
Location (UCSC)	Chr 2: 28.75 – 28.8 Mb	Chr 5: 32.46 – 32.52 Mb
PubMed search

5500

19046

ENSG00000213639

ENSMUSG00000014956

P62140

P62141

NM_206877
NM_002709
NM_206876

NM_172707

NP_002700
NP_996759

NP_766295.2
NP_766295

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.

PPP1CB has been shown to interact with PPP1R15A,Nucleolin,SMARCB1 and PPP1R9B.

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Wikipedia