SMARCB1

SMARCB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AJ1
Identifiers
Aliases	SMARCB1, BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS, CSS3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
External IDs	MGI: 1328366 HomoloGene: 2310 GeneCards: SMARCB1
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • RNA polymerase I CORE element sequence-specific DNA binding • transcription coactivator activity • p53 binding • Tat protein binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • nucleosomal DNA binding Cellular component • nBAF complex • SWI/SNF complex • nucleoplasm • protein complex • XY body • nuclear chromosome • npBAF complex • nucleolus • nuclear chromatin • BAF-type complex • nucleus • fibrillar center • intracellular membrane-bounded organelle Biological process • positive regulation of glucose mediated signaling pathway • chromatin remodeling • cell differentiation • regulation of transcription, DNA-templated • DNA integration • positive regulation of histone H3-K9 acetylation • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter • positive regulation of sequence-specific DNA binding transcription factor activity • transcription, DNA-templated • nervous system development • ATP-dependent chromatin remodeling • nucleosome disassembly • positive regulation of histone H4 acetylation • single stranded viral RNA replication via double stranded DNA intermediate • cell cycle • negative regulation of histone H3-K9 trimethylation • regulation of histone H4-K16 acetylation • viral process • negative regulation of histone H3-K9 dimethylation • DNA repair • positive regulation by host of viral transcription • blastocyst development • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • blastocyst hatching • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6598	20587
Ensembl	n/a	ENSMUSG00000000902
UniProt	Q12824	Q9Z0H3
RefSeq (mRNA)	NM_001007468 NM_003073 NM_001317946	NM_001161853 NM_011418
RefSeq (protein)	NP_001007469 NP_001304875 NP_003064	NP_035548.1 NP_001155325 NP_035548
Location (UCSC)	Chr 22: 23.79 – 23.83 Mb	Chr 10: 75.9 – 75.92 Mb
PubMed search

5AJ1

6598

20587

n/a

ENSMUSG00000000902

Q12824

Q9Z0H3

NM_001007468
NM_003073
NM_001317946

NM_001161853
NM_011418

NP_001007469
NP_001304875
NP_003064

NP_035548.1
NP_001155325
NP_035548

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.

...
Wikipedia