PPP1R15A

PPP1R15A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XPN
Identifiers
Aliases	PPP1R15A, GADD34, protein phosphatase 1 regulatory subunit 15A
External IDs	MGI: 1927072 HomoloGene: 8639 GeneCards: PPP1R15A
Gene ontology Molecular function • protein binding • protein phosphatase binding • protein kinase binding • protein phosphatase 1 binding • protein phosphatase regulator activity • protein phosphatase activator activity Cellular component • Golgi apparatus • endoplasmic reticulum membrane • membrane • mitochondrial outer membrane • protein phosphatase type 1 complex • endoplasmic reticulum • mitochondrion • cytosol • cytoplasm Biological process • negative regulation of protein dephosphorylation • regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation • positive regulation of peptidyl-serine dephosphorylation • response to endoplasmic reticulum stress • cellular response to DNA damage stimulus • positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation • endoplasmic reticulum unfolded protein response • peptidyl-serine dephosphorylation • positive regulation of translational initiation in response to stress • positive regulation of phosphoprotein phosphatase activity • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • cell cycle arrest • negative regulation of phosphoprotein phosphatase activity • protein localization to endoplasmic reticulum • negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation • regulation of translational initiation by eIF2 alpha dephosphorylation • negative regulation of response to endoplasmic reticulum stress • negative regulation of PERK-mediated unfolded protein response • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • regulation of translation • apoptotic process • positive regulation of gene expression • positive regulation of transcription from RNA polymerase I promoter • positive regulation of peptidyl-serine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23645	17872
Ensembl	ENSG00000087074	ENSMUSG00000040435
UniProt	O75807	P17564
RefSeq (mRNA)	NM_014330	NM_008654
RefSeq (protein)	NP_055145	NP_032680
Location (UCSC)	Chr 19: 48.87 – 48.88 Mb	Chr 7: 45.52 – 45.53 Mb
PubMed search

4XPN

23645

17872

ENSG00000087074

ENSMUSG00000040435

O75807

P17564

NM_014330

NM_008654

NP_055145

NP_032680

Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a protein that in humans is encoded by the PPP1R15A gene.

The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically suppress cell growth. Later on it has been characterized as a gene playing a role in ER stress-induced cell death, being a target of ATF4 that plays a role in ER-mediated cell death via promoting protein dephosphorylation of eIF2α and reversing translational inhibition.

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

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Wikipedia