ATF4

ATF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CI6
Identifiers
Aliases	ATF4, CREB-2, CREB2, TAXREB67, TXREB, activating transcription factor 4
External IDs	MGI: 88096 HomoloGene: 1266 GeneCards: ATF4
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II transcription factor binding • leucine zipper domain binding • protein C-terminus binding • protein binding • protein heterodimerization activity • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • DNA binding • core promoter sequence-specific DNA binding • sequence-specific DNA binding Cellular component • Lewy body core • nuclear periphery • membrane • transcription factor complex • plasma membrane • dendrite membrane • nucleoplasm • microtubule organizing center • neuron projection • cytoskeleton • CHOP-ATF4 complex • ATF4-CREB1 transcription factor complex • cytoplasm • nucleus • ATF1-ATF4 transcription factor complex Biological process • gamma-aminobutyric acid signaling pathway • positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance • cellular response to glucose starvation • negative regulation of translational initiation in response to stress • rhythmic process • cellular response to UV • positive regulation of transcription from RNA polymerase II promoter in response to stress • regulation of transcription from RNA polymerase II promoter • cellular amino acid metabolic process • transcription from RNA polymerase II promoter • transcription, DNA-templated • response to manganese-induced endoplasmic reticulum stress • positive regulation of gene expression • circadian rhythm • negative regulation of potassium ion transport • positive regulation of apoptotic process • positive regulation of vascular endothelial growth factor production • positive regulation of transcription from RNA polymerase I promoter • positive regulation of transcription from RNA polymerase II promoter • positive regulation of neuron apoptotic process • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • gluconeogenesis • PERK-mediated unfolded protein response • regulation of transcription, DNA-templated • negative regulation of oxidative stress-induced neuron death • cellular response to amino acid starvation • circadian regulation of gene expression • positive regulation of transcription, DNA-templated • mRNA transcription from RNA polymerase II promoter • response to endoplasmic reticulum stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	468	11911
Ensembl	ENSG00000128272	ENSMUSG00000042406
UniProt	P18848 Q96AQ3	Q06507
RefSeq (mRNA)	NM_182810 NM_001675	NM_001287180 NM_009716
RefSeq (protein)	NP_001666 NP_877962 NP_001666.2 NP_877962.1	NP_001274109.1 NP_033846.2 NP_001274109 NP_033846
Location (UCSC)	Chr 22: 39.52 – 39.52 Mb	Chr 15: 80.26 – 80.26 Mb
PubMed search

1CI6

468

11911

ENSG00000128272

ENSMUSG00000042406

P18848
Q96AQ3

Q06507

NM_182810
NM_001675

NM_001287180
NM_009716

NP_001666
NP_877962
NP_001666.2
NP_877962.1

NP_001274109.1
NP_033846.2
NP_001274109
NP_033846

Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.

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