PPP1R9B

Identifiers

PPP1R9B, PPP1R6, PPP1R9, SPINO, Spn, protein phosphatase 1 regulatory subunit 9B

External IDs

MGI: 2387581 HomoloGene: 32787 GeneCards: PPP1R9B

Gene ontology
Molecular function	• protein phosphatase 1 binding • protein binding • protein phosphatase inhibitor activity • actin binding
Cellular component	• cytoplasm • cell projection • membrane • filopodium • adherens junction • plasma membrane • dendritic spine • synapse • nucleoplasm • ruffle membrane • cell junction • protein phosphatase type 1 complex • cytoskeleton • nucleus • lamellipodium
Biological process	• cell differentiation • regulation of opioid receptor signaling pathway • filopodium assembly • regulation of cell growth by extracellular stimulus • modulation of synaptic transmission • nervous system development • multicellular organism development • regulation of cell proliferation • negative regulation of cell growth • cell cycle arrest • RNA splicing • cellular response to morphine • cell migration • regulation of exit from mitosis • negative regulation of catalytic activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


84687


217124

Ensembl


ENSG00000108819


ENSMUSG00000038976

UniProt


Q96SB3


Q6R891

RefSeq (mRNA)


NM_032595


NM_172261

RefSeq (protein)


NP_115984


NP_758465.2 NP_758465

Location (UCSC)

Chr 17: 50.13 – 50.15 Mb

Chr 11: 94.99 – 95.01 Mb

PubMed search

NP_758465.2
NP_758465

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM]

PPP1R9B has been shown to interact with PPP1CB,PPP1CA,Dopamine receptor D2,P16,PPP1CC,T-cell lymphoma invasion and metastasis-inducing protein 1 and PPP1R2.

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Wikipedia