PAX7

Identifiers

PAX7, HUP1, PAX7B, RMS2, Pax7, paired box 7

External IDs

Gene ontology
Molecular function	• sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter sequence-specific
Cellular component	• nucleus
Biological process	• positive regulation of myoblast proliferation • regulation of cell fate commitment • chromatin remodeling • regulation of transcription, DNA-templated • spinal cord association neuron differentiation • positive regulation of histone methylation • anatomical structure morphogenesis • muscle organ development • negative regulation of apoptotic process • transcription, DNA-templated • embryonic skeletal system development • multicellular organism development • cartilage development • skeletal muscle tissue regeneration • muscle tissue morphogenesis • regulation of gene expression • neuron fate commitment • skeletal muscle satellite cell commitment • dorsal/ventral neural tube patterning • regulation of protein binding • skeletal muscle tissue development • positive regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5081


18509


ENSG00000009709


ENSMUSG00000028736


P23759


P47239

RefSeq (mRNA)


NM_013945 NM_001135254 NM_002584


NM_011039

RefSeq (protein)


NP_001128726 NP_002575 NP_039236


NP_035169.1 NP_035169

Location (UCSC)

PubMed search

Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.

Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. PAX7 is expressed in the palatal shelf of the maxilla, Meckel's cartilage, mesencephalon, nasal cavity, nasal epithelium, nasal capsule and pons.