SNAI2

SNAI2
Identifiers
Aliases	SNAI2, SLUG, SLUGH1, SNAIL2, WS2D, snail family transcriptional repressor 2, SLUGH
External IDs	MGI: 1096393 HomoloGene: 31127 GeneCards: SNAI2
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • chromatin binding • metal ion binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • cytoplasm • nuclear chromatin • Q40260 • nucleoplasm Biological process • Notch signaling pathway • regulation of branching involved in salivary gland morphogenesis • cell migration involved in endocardial cushion formation • palate development • negative regulation of stem cell proliferation • negative regulation of vitamin D receptor signaling pathway • regulation of transcription, DNA-templated • neural crest cell development • negative regulation of keratinocyte proliferation • regulation of bicellular tight junction assembly • positive regulation of cell migration • epithelial to mesenchymal transition involved in endocardial cushion formation • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • sensory perception of sound • cellular response to fibroblast growth factor stimulus • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • transcription, DNA-templated • epithelium development • positive regulation of histone acetylation • cellular response to epidermal growth factor stimulus • negative regulation of cell adhesion involved in substrate-bound cell migration • negative regulation of vitamin D biosynthetic process • regulation of chemokine production • multicellular organism development • negative regulation of chondrocyte differentiation • negative regulation of DNA damage response, signal transduction by p53 class mediator • regulation of osteoblast differentiation • osteoblast differentiation • epithelial to mesenchymal transition • cellular response to ionizing radiation • white fat cell differentiation • canonical Wnt signaling pathway • cartilage morphogenesis • negative regulation of catenin import into nucleus • pigmentation • response to radiation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of fat cell differentiation • cell migration • negative regulation of canonical Wnt signaling pathway • negative regulation of cell adhesion mediated by integrin • negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter • desmosome disassembly • negative regulation of anoikis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6591	20583
Ensembl	ENSG00000019549	ENSMUSG00000022676
UniProt	O43623	P97469
RefSeq (mRNA)	NM_003068	NM_011415
RefSeq (protein)	NP_003059	NP_035545
Location (UCSC)	Chr 8: 48.92 – 48.92 Mb	Chr 16: 14.71 – 14.71 Mb
PubMed search

6591

20583

ENSG00000019549

ENSMUSG00000022676

O43623

P97469

NM_003068

NM_011415

NP_003059

NP_035545

Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene.

This gene encodes a member of the Snail superfamily of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. It regulates differentiation and migration of neural crest cells along with other genes (e.g. FOXD3, SOX9 and SOX10, BMPs) in embryonic life. Mutations in this gene may be associated with sporadic cases of neural tube defects.

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