SOX10

SOX10
Identifiers
Aliases	SOX10, DOM, PCWH, WS2E, WS4, WS4C, SRY-box 10
External IDs	MGI: 98358 HomoloGene: 5055 GeneCards: SOX10
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription factor binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription factor binding • protein binding • identical protein binding • transcription regulatory region DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cytoplasm • nucleoplasm • extrinsic component of mitochondrial outer membrane • nucleus Biological process • positive regulation of neuroblast proliferation • cell differentiation • peripheral nervous system development • regulation of transcription, DNA-templated • morphogenesis of a branching epithelium • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • oligodendrocyte differentiation • negative regulation of apoptotic process • in utero embryonic development • cell maturation • transcription from RNA polymerase II promoter • transcription, DNA-templated • stem cell differentiation • positive regulation of transcription, DNA-templated • enteric nervous system development • developmental growth • neural crest cell migration • melanocyte differentiation • negative regulation of transcription, DNA-templated • negative regulation of canonical Wnt signaling pathway • lacrimal gland development • positive regulation of transcription from RNA polymerase II promoter • digestive tract morphogenesis • positive regulation of gliogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6663	20665
Ensembl	ENSG00000100146	ENSMUSG00000033006
UniProt	P56693	Q04888
RefSeq (mRNA)	NM_006941	NM_011437
RefSeq (protein)	NP_008872	NP_035567.1 NP_035567
Location (UCSC)	Chr 22: 37.97 – 37.99 Mb	Chr 15: 79.15 – 79.16 Mb
PubMed search

6663

20665

ENSG00000100146

ENSMUSG00000033006

P56693

Q04888

NM_006941

NM_011437

NP_008872

NP_035567.1
NP_035567

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and determination of cell fate. The encoded protein act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development.

In melanocytic cells there is evidence that SOX10 gene expression may be regulated by MITF.

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Wikipedia