Microphthalmia-associated transcription factor

MITF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C7N
Identifiers
Aliases	MITF, CMM8, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, melanogenesis associated transcription factor
External IDs	OMIM: 156845 MGI: 104554 HomoloGene: 4892 GeneCards: MITF
Gene ontology Molecular function • DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • E-box binding Cellular component • nucleoplasm • protein complex • nucleus Biological process • regulation of RNA biosynthetic process • protein complex assembly • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • positive regulation of DNA-templated transcription, initiation • protein sumoylation • transcription, DNA-templated • multicellular organism development • positive regulation of transcription, DNA-templated • positive regulation of gene expression • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • melanocyte differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4286	17342
Ensembl	ENSG00000187098	ENSMUSG00000035158
UniProt	O75030	Q08874
RefSeq (mRNA)	NM_000248 NM_001184967 NM_001184968 NM_006722 NM_198158 NM_198159 NM_198177 NM_198178	NM_001113198 NM_001178049 NM_008601
RefSeq (protein)	NP_000239 NP_001171896 NP_001171897 NP_006713 NP_937801 NP_937802 NP_937820 NP_937821	NP_032627.1 NP_001106669 NP_001171520 NP_032627
Location (UCSC)	Chr 3: 69.74 – 69.97 Mb	Chr 6: 97.81 – 98.02 Mb
PubMed search

4C7N

4286

17342

ENSG00000187098

ENSMUSG00000035158

O75030

Q08874

NM_198159
NM_198177
NM_198178

NM_001113198
NM_001178049
NM_008601

NP_937802
NP_937820
NP_937821

NP_032627.1
NP_001106669
NP_001171520
NP_032627

Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene.

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Wikipedia