B3GAT1

B3GAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V82, 1V83, 1V84
Identifiers
Aliases	B3GAT1, CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, beta-1,3-glucuronyltransferase 1
External IDs	MGI: 1924148 HomoloGene: 49551 GeneCards: B3GAT1
Gene ontology Molecular function • transferase activity • metal ion binding • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity • UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Cellular component • integral component of membrane • Golgi apparatus • membrane • extracellular region • endoplasmic reticulum • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • Golgi membrane Biological process • glycosaminoglycan metabolic process • protein glycosylation • chondroitin sulfate proteoglycan biosynthetic process • carbohydrate metabolic process • chondroitin sulfate metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27087	76898
Ensembl	ENSG00000109956	ENSMUSG00000045994
UniProt	Q9P2W7	Q9CW73
RefSeq (mRNA)	NM_018644 NM_054025	NM_029792 NM_001310766
RefSeq (protein)	NP_061114 NP_473366	NP_001297695 NP_084068
Location (UCSC)	Chr 11: 134.38 – 134.41 Mb	Chr 9: 26.73 – 26.76 Mb
PubMed search

1V82, 1V83, 1V84

27087

76898

ENSG00000109956

ENSMUSG00000045994

Q9P2W7

Q9CW73

NM_018644
NM_054025

NM_029792
NM_001310766

NP_061114
NP_473366

NP_001297695
NP_084068

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system.

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