ORC2L

ORC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5C8H
Identifiers
Aliases	ORC2, ORC2L, origin recognition complex subunit 2
External IDs	MGI: 1328306 HomoloGene: 4512 GeneCards: ORC2
Gene ontology Molecular function • protein binding • DNA replication origin binding Cellular component • heterochromatin • condensed chromosome inner kinetochore • nuclear origin of replication recognition complex • centrosome • chromatin • origin recognition complex • membrane • nuclear chromosome, telomeric region • nucleus • nucleoplasm Biological process • G1/S transition of mitotic cell cycle • DNA replication • negative regulation of transcription from RNA polymerase II promoter • DNA replication initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4999	18393
Ensembl	ENSG00000115942	ENSMUSG00000026037
UniProt	Q13416	Q60862
RefSeq (mRNA)	NM_006190	NM_001025378 NM_001271526 NM_008765
RefSeq (protein)	NP_006181	NP_001258455.1 NP_032791.1 NP_001020549 NP_001258455 NP_032791
Location (UCSC)	Chr 2: 200.91 – 200.96 Mb	Chr 1: 58.46 – 58.51 Mb
PubMed search

Origin recognition complex subunit 2
Identifiers
Symbol	ORC2
Pfam	PF04084
InterPro	IPR007220
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

5C8H

4999

18393

ENSG00000115942

ENSMUSG00000026037

Q13416

Q60862

NM_006190

NM_001025378
NM_001271526
NM_008765

NP_006181

NP_001258455.1
NP_032791.1
NP_001020549
NP_001258455
NP_032791

Origin recognition complex subunit 2 is a protein that in humans is encoded by the ORC2 (ORC2L) gene.

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, ORC4, and ORC5. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.

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Wikipedia