ORC4

ORC4
Identifiers
Aliases	ORC4, ORC4L, ORC4P, origin recognition complex subunit 4
External IDs	MGI: 1347043 HomoloGene: 8059 GeneCards: ORC4
Gene ontology Molecular function • nucleotide binding • DNA binding • DNA replication origin binding • protein binding • ATP binding Cellular component • nuclear origin of replication recognition complex • nucleolus • origin recognition complex • nuclear chromosome, telomeric region • nucleus • nucleoplasm • cytosol Biological process • G1/S transition of mitotic cell cycle • DNA replication • DNA replication initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5000	26428
Ensembl	ENSG00000115947	ENSMUSG00000026761
UniProt	O43929	O88708
RefSeq (mRNA)	NM_001190879 NM_001190881 NM_001190882 NM_002552 NM_181741 NM_181742	NM_001177313 NM_011958
RefSeq (protein)	NP_001177808 NP_001177810 NP_001177811 NP_002543 NP_859525 NP_859526	NP_036088.3 NP_001170784 NP_036088
Location (UCSC)	Chr 2: 147.93 – 148.02 Mb	Chr 2: 48.9 – 48.95 Mb
PubMed search

5000

26428

ENSG00000115947

ENSMUSG00000026761

O43929

O88708

NM_181742

NM_001177313
NM_011958

NP_859526

NP_036088.3
NP_001170784
NP_036088

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.

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