Cdc6

CDC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CCH, 2CCI, 4I5L, 4I5N
Identifiers
Aliases	CDC6, CDC18L, HsCDC18, Hscell division cycle 6
External IDs	MGI: 1345150 HomoloGene: 68172 GeneCards: CDC6
Gene ontology Molecular function • nucleotide binding • kinase binding • protein binding • ATP binding Cellular component • Golgi apparatus • spindle pole • nucleoplasm • spindle midzone • nucleus • cytoplasm • cytosol Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • mitotic nuclear division • cellular response to vasopressin • positive regulation of fibroblast proliferation • G1/S transition of mitotic cell cycle • negative regulation of DNA replication • regulation of transcription involved in G1/S transition of mitotic cell cycle • cell division • positive regulation of cytokinesis • DNA replication checkpoint • DNA replication • cellular response to angiotensin • DNA replication initiation • traversing start control point of mitotic cell cycle • positive regulation of chromosome segregation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of mitotic metaphase/anaphase transition • cell cycle • negative regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	990	23834
Ensembl	ENSG00000094804	ENSMUSG00000017499
UniProt	Q99741	O89033
RefSeq (mRNA)	NM_001254	NM_001025779 NM_011799
RefSeq (protein)	NP_001245	NP_001020950.1 NP_035929.1 NP_001020950 NP_035929
Location (UCSC)	Chr 17: 40.29 – 40.3 Mb	Chr 11: 98.91 – 98.92 Mb
PubMed search

2CCH, 2CCI, 4I5L, 4I5N

990

23834

ENSG00000094804

ENSMUSG00000017499

Q99741

O89033

NM_001254

NM_001025779
NM_011799

NP_001245

NP_001020950.1
NP_035929.1
NP_001020950
NP_035929

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.

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Wikipedia