CDC45L

CDC45
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DGO
Identifiers
Aliases	CDC45, CDC45L, CDC45L2, PORC-PI-1, CDC45-related protein, cell division cycle 45, MGORS7
External IDs	MGI: 1338073 HomoloGene: 2616 GeneCards: CDC45
Gene ontology Molecular function • chromatin binding • single-stranded DNA binding • protein binding • DNA replication origin binding • 3'-5' DNA helicase activity Cellular component • cytoplasm • DNA replication preinitiation complex • centrosome • nuclear pre-replicative complex • replication fork protection complex • nucleoplasm • nucleus Biological process • double-strand break repair via break-induced replication • G1/S transition of mitotic cell cycle • regulation of transcription involved in G1/S transition of mitotic cell cycle • pre-replicative complex assembly involved in nuclear cell cycle DNA replication • DNA replication checkpoint • positive regulation of G1/S transition of mitotic cell cycle • DNA replication • cell cycle • regulation of chromatin silencing at telomere • mitotic DNA replication preinitiation complex assembly • DNA duplex unwinding • DNA replication initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8318	12544
Ensembl	ENSG00000093009	ENSMUSG00000000028
UniProt	O75419	Q9Z1X9
RefSeq (mRNA)	NM_001178010 NM_001178011 NM_003504	NM_001161623 NM_009862
RefSeq (protein)	NP_001171481 NP_001171482 NP_003495	NP_001155095 NP_033992
Location (UCSC)	Chr 22: 19.48 – 19.52 Mb	Chr 16: 18.78 – 18.81 Mb
PubMed search

5DGO

8318

12544

ENSG00000093009

ENSMUSG00000000028

O75419

Q9Z1X9

NM_001178010
NM_001178011
NM_003504

NM_001161623
NM_009862

NP_001171481
NP_001171482
NP_003495

NP_001155095
NP_033992

CDC45 is a protein that in humans is encoded by the CDC45L gene.

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.

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Wikipedia