ORC3

Origin recognition complex (ORC) subunit 3 N-terminus
Identifiers
Symbol	ORC3_N
Pfam	PF07034
InterPro	IPR010748
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ORC3
Identifiers
Aliases	ORC3, LAT, LATHEO, ORC3L, origin recognition complex subunit 3
External IDs	MGI: 1354944 HomoloGene: 8225 GeneCards: ORC3
Gene ontology Molecular function • DNA binding • DNA replication origin binding • protein binding Cellular component • nuclear origin of replication recognition complex • origin recognition complex • nuclear chromosome, telomeric region • nucleus • nucleoplasm • nuclear pre-replicative complex • DNA replication preinitiation complex • nuclear body Biological process • G1/S transition of mitotic cell cycle • DNA replication • neural precursor cell proliferation • DNA replication initiation • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23595	50793
Ensembl	ENSG00000135336	ENSMUSG00000040044
UniProt	Q9UBD5	Q9JK30
RefSeq (mRNA)	NM_001197259 NM_012381 NM_181837	NM_001159563 NM_015824
RefSeq (protein)	NP_001184188 NP_036513 NP_862820	NP_001153035.1 NP_056639.3 NP_001153035 NP_056639
Location (UCSC)	Chr 6: 87.59 – 87.67 Mb	Chr 4: 34.57 – 34.61 Mb
PubMed search

23595

50793

ENSG00000135336

ENSMUSG00000040044

Q9UBD5

Q9JK30

NM_001197259
NM_012381
NM_181837

NM_001159563
NM_015824

NP_001184188
NP_036513
NP_862820

NP_001153035.1
NP_056639.3
NP_001153035
NP_056639

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

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