North Carolina Highway 42
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Route of NC 42 highlighted in red
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| Route information | ||||
| Maintained by NCDOT | ||||
| Length: | 222.9 mi (358.7 km) | |||
| Existed: | 1922 – present | |||
| Major junctions | ||||
| West end: |
   I‑73 / I‑74 / US 220 in Asheboro
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   US 1 / US 15 / US 501 in Sanford US 421 in Sanford I‑40 near Cleveland, Johnston County US 70 in Clayton I‑95 near Wilson US 264 near Wilson US 301 in Wilson US 258 near Pinetops US 64 near Bethel US 13 in Ahoskie
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| East end: |
 NC 45 in Colerain
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| Location | ||||
| Counties: | Randolph, Chatham, Lee, Wake, Johnston, Wilson, Edgecombe, Bertie, Martin, Hertford | |||
| Highway system | ||||
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North Carolina Highway 42 (NC 42) is a 223-mile-long (359 km) state highway and a semi-urban traffic artery connecting Asheboro, Sanford, Clayton, Wilson and Ahoskie as well as many small to medium-sized towns throughout Central and Eastern North Carolina. The highway is primarily rural, avoiding larger cities such as Raleigh. NC 42 begins at Interstate 73 (I-73)/I-74/US Highway 220 (US 220) on the western side of Asheboro. From there the highway runs southeast toward Sanford. Running through the heart of Sanford, NC 42 intersects several major highways such as US 1 and US 421. Leaving Sanford the highway runs along the southern side of the Triangle Area, while servicing the smaller towns of Fuquay-Varina and Clayton. Further east the highway intersects both I-95 and US 264, shortly before entering into central Wilson. Leaving Wilson the highway continues to the northeast, and intersects US 258 near Crisp. North of intersecting US 64, NC 42 begins a concurrency with NC 11 from Hassell to western Ahoskie. Nearing Ahoskie the highway turns to the east and runs south of the center of the town. NC 42 follows concurrently with US 13 southeast to Powellville. Nearing its eastern terminus the highway turns east along its own routing until reaching NC 45 in Colerain where the highway ends.
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