Nord-Pas-de-Calais (French pronunciation: [nɔʁ pɑ d(ə) ka.lɛ], is a former administrative region of France. Since 1 January 2016, it is part of the new region Hauts-de-France. It consisted of the departments of Nord and Pas-de-Calais. Nord-Pas-de-Calais borders the English Channel (west), the North Sea (northwest), Belgium (north and east) and Picardy (south). The majority of the region was once part of the , but gradually became part of France between 1477 and 1678, particularly during the reign of king Louis XIV. The historical French provinces that preceded Nord-Pas-de-Calais are Artois, French Flanders, French Hainaut and (partially) Picardy. These provincial designations are still frequently used by the inhabitants.

With its 330.8 people per km² on just over 12,414 km², it is a densely populated region, having some 4.1 million inhabitants, 7% of France's total population, making it the fourth most populous region in the country, 83% of whom live in urban communities. Its administrative centre and largest city is Lille. The second largest city is Calais, which serves as a major continental economic/transportation hub with Dover of Great Britain 42 kilometres (26 mi) away; this makes Nord-Pas-de-Calais the closest continental European connection to the Great Britain. Other major towns include Valenciennes, Lens, Douai, Béthune, Dunkirk, Maubeuge, Boulogne, Arras, Cambrai and Saint-Omer.

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