NR2B

GRIN2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EWM, 5EWL, 5EWJ
Identifiers
Aliases	GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B
External IDs	MGI: 95821 HomoloGene: 646 GeneCards: GRIN2B
Gene ontology Molecular function • zinc ion binding • NMDA glutamate receptor activity • glycine binding • metal ion binding • ion channel activity • protein binding • ionotropic glutamate receptor activity • extracellular-glutamate-gated ion channel activity • receptor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • NMDA selective glutamate receptor complex • cell surface • cell junction • neuron projection • intracellular Biological process • glutamate receptor signaling pathway • ephrin receptor signaling pathway • ion transport • MAPK cascade • ion transmembrane transport • transport • learning or memory • response to ethanol • chemical synaptic transmission • positive regulation of GTPase activity • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • regulation of ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2904	14812
Ensembl	ENSG00000273079	ENSMUSG00000030209
UniProt	Q13224	Q01097
RefSeq (mRNA)	NM_000834	NM_008171
RefSeq (protein)	NP_000825	NP_032197.3 NP_032197
Location (UCSC)	Chr 12: 13.44 – 13.98 Mb	Chr 6: 135.71 – 136.17 Mb
PubMed search

5EWM, 5EWL, 5EWJ

2904

14812

ENSG00000273079

ENSMUSG00000030209

Q13224

Q01097

NM_000834

NM_008171

NP_000825

NP_032197.3
NP_032197

Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene.

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. The NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heterotetramers composed of two molecules of the key receptor subunit NMDAR1 (GRIN1) and two drawn from one or more of the four NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate, one of the predominant excitatory neurotransmitter receptors in the mammalian brain.

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Wikipedia