GRIN2C

GRIN2C
Identifiers
Aliases	GRIN2C, GluN2C, NMDAR2C, NR2C, glutamate ionotropic receptor NMDA type subunit 2C
External IDs	MGI: 95822 HomoloGene: 647 GeneCards: GRIN2C
Targeted by Drug
glycine, L-Aspartic Acid, homoquinolinic acid, Tetrazolylglycine, N-methyl-D-aspartic acid, 5,7-dichlorokynurenic acid, d-CCPene, selfotel, amantadine, dextromethorphan, dizocilpine, ketamine, levorphanol, phencyclidine
Gene ontology Molecular function • NMDA glutamate receptor activity • ion channel activity • protein binding • ionotropic glutamate receptor activity • cation channel activity • extracellular-glutamate-gated ion channel activity • receptor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • postsynaptic density • plasma membrane • synapse • integral component of plasma membrane • cell junction • intracellular • NMDA selective glutamate receptor complex Biological process • protein localization • glutamate receptor signaling pathway • neuromuscular process controlling balance • negative regulation of protein catabolic process • regulation of membrane potential • directional locomotion • ion transport • cation transmembrane transport • MAPK cascade • ionotropic glutamate receptor signaling pathway • response to wounding • excitatory postsynaptic potential • transport • ion transmembrane transport • positive regulation of GTPase activity • regulation of ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2905	14813
Ensembl	ENSG00000161509	ENSMUSG00000020734
UniProt	Q14957	Q01098
RefSeq (mRNA)	NM_000835 NM_001278553	NM_010350
RefSeq (protein)	NP_000826 NP_001265482	NP_034480.2 NP_034480
Location (UCSC)	Chr 17: 74.84 – 74.86 Mb	Chr 11: 115.25 – 115.27 Mb
PubMed search

2905

14813

ENSG00000161509

ENSMUSG00000020734

Q14957

Q01098

NM_000835
NM_001278553

NM_010350

NP_000826
NP_001265482

NP_034480.2
NP_034480

Glutamate [NMDA] receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene.

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

GRIN2C has been shown to interact with DLG4 and DLG3.

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Wikipedia