Selfotel

Selfotel
Legal status

Legal status	In general: legal
Identifiers
IUPAC name (2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid
Synonyms	Selfotel
CAS Number	110347-85-8^Y
PubChem CID	68736
IUPHAR/BPS	4155
ChemSpider	61982^N
UNII	4VGJ4A41L2
KEGG	D02410^Y
ChEMBL	CHEMBL39664^N
Chemical and physical data
Formula	C₇H₁₄NO₅P
Molar mass	223.164 g/mol
3D model (Jmol)	Interactive image
SMILES C1CN[C@@H](C[C@@H]1CP(=O)(O)O)C(=O)O
InChI InChI=1S/C7H14NO5P/c9-7(10)6-3-5(1-2-8-6)4-14(11,12)13/h5-6,8H,1-4H2,(H,9,10)(H2,11,12,13)/t5-,6+/m1/s1^N Key:LPMRCCNDNGONCD-RITPCOANSA-N^N
^NY (what is this?)

Selfotel (CGS-19755) is a drug which acts as a competitive NMDA antagonist, directly competing with glutamate for binding to the receptor. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.

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