GRIN2D

GRIN2D
Identifiers
Aliases	GRIN2D, EB11, GluN2D, NMDAR2D, NR2D, glutamate ionotropic receptor NMDA type subunit 2D, EIEE46
External IDs	MGI: 95823 HomoloGene: 648 GeneCards: GRIN2D
Gene ontology Molecular function • ion channel activity • protein binding • extracellular-glutamate-gated ion channel activity • receptor activity • Ras guanyl-nucleotide exchange factor activity • ionotropic glutamate receptor activity • NMDA glutamate receptor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • cell junction • intracellular Biological process • startle response • regulation of sensory perception of pain • adult locomotory behavior • ion transport • MAPK cascade • ion transmembrane transport • ionotropic glutamate receptor signaling pathway • transport • signal transduction • positive regulation of GTPase activity • excitatory postsynaptic potential • regulation of ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2906	14814
Ensembl	ENSG00000105464	ENSMUSG00000002771
UniProt	O15399	Q03391
RefSeq (mRNA)	NM_000836	NM_008172
RefSeq (protein)	NP_000827	NP_032198.2 NP_032198
Location (UCSC)	Chr 19: 48.39 – 48.44 Mb	Chr 7: 45.83 – 45.88 Mb
PubMed search

2906

14814

ENSG00000105464

ENSMUSG00000002771

O15399

Q03391

NM_000836

NM_008172

NP_000827

NP_032198.2
NP_032198

Glutamate [NMDA] receptor subunit epsilon-4 is a protein that in humans is encoded by the GRIN2D gene.

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

GRIN2D has been shown to interact with Interleukin 16.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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