GRIN1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2HQW, 2NR1, 3BYA, 5H8N, 5H8H, 5H8Q, 5H8F, 5I2N, 5I2K, 5KCJ, 5KDT

Identifiers

Aliases

GRIN1, GluN1, MRD8, NMDA1, NMDAR1, NR1, NMD-R1, glutamate ionotropic receptor NMDA type subunit 1

External IDs

MGI: 95819 HomoloGene: 7187 GeneCards: GRIN1

Targeted by Drug

glycine, L-Aspartic Acid, Tetrazolylglycine, N-methyl-D-aspartic acid, homoquinolinic acid, 5,7-dichlorokynurenic acid

Gene ontology
Molecular function	• calcium ion binding • receptor binding • glycine binding • calmodulin binding • protein binding • cation channel activity • extracellular-glutamate-gated ion channel activity • glutamate binding • receptor activity • calcium channel activity • NMDA glutamate receptor activity • ion channel activity • ionotropic glutamate receptor activity • neurotransmitter binding • Ras guanyl-nucleotide exchange factor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component	• cytoplasm • postsynaptic membrane • membrane • synapse • NMDA selective glutamate receptor complex • neuron projection • synaptic vesicle • dendritic spine • cell surface • endoplasmic reticulum • integral component of membrane • plasma membrane • postsynaptic density • integral component of plasma membrane • excitatory synapse • cell junction • dendrite • synaptic cleft • terminal bouton • postsynaptic density membrane
Biological process	• negative regulation of neuron apoptotic process • pons maturation • synaptic transmission, glutamatergic • regulation of respiratory gaseous exchange • response to amphetamine • regulation of membrane potential • regulation of synapse assembly • learning • positive regulation of excitatory postsynaptic potential • response to ethanol • calcium ion transport • suckling behavior • prepulse inhibition • male mating behavior • regulation of long-term neuronal synaptic plasticity • adult locomotory behavior • regulation of neuron apoptotic process • ion transport • memory • regulation of axonogenesis • neuromuscular process • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • learning or memory • social behavior • regulation of neuronal synaptic plasticity • associative learning • startle response • calcium ion homeostasis • cation transport • cellular calcium ion homeostasis • cation transmembrane transport • respiratory gaseous exchange • regulation of synaptic plasticity • response to morphine • propylene metabolic process • conditioned taste aversion • cerebral cortex development • transport • sensory perception of pain • olfactory learning • regulation of cell communication • visual learning • ephrin receptor signaling pathway • MAPK cascade • regulation of dendrite morphogenesis • ion transmembrane transport • long-term memory • positive regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • calcium ion transmembrane transport • regulation of ion transmembrane transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2902


14810

Ensembl


ENSG00000176884


ENSMUSG00000026959

UniProt


Q05586


P35438

RefSeq (mRNA)


NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569


NM_001177656 NM_001177657 NM_008169

RefSeq (protein)


NP_000823 NP_001172019 NP_001172020 NP_015566 NP_067544

NP_001171127.1 NP_001171128.1 NP_032195.1 NP_001171127 NP_001171128
NP_032195

Location (UCSC)

Chr 9: 137.14 – 137.17 Mb

Chr 2: 25.29 – 25.32 Mb

PubMed search

2HQW, 2NR1, 3BYA, 5H8N, 5H8H, 5H8Q, 5H8F, 5I2N, 5I2K, 5KCJ, 5KDT

NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569

NM_001177656
NM_001177657
NM_008169

...
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