GRIN2A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3NFL, 5H8Q, 5H8H, 5H8N, 5H8F, 5I2N, 5I2K, 5KDT, 5KCJ

Identifiers

Aliases

GRIN2A, EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, glutamate ionotropic receptor NMDA type subunit 2A

External IDs

MGI: 95820 HomoloGene: 645 GeneCards: GRIN2A

Genetically Related Diseases

hepatitis B

Targeted by Drug

glycine, L-Aspartic Acid, homoquinolinic acid, Tetrazolylglycine, N-methyl-D-aspartic acid, 5,7-dichlorokynurenic acid, d-CCPene, selfotel, amantadine, dizocilpine, ketamine, phencyclidine

Gene ontology
Molecular function	• calcium channel activity • zinc ion binding • NMDA glutamate receptor activity • metal ion binding • ion channel activity • protein binding • ionotropic glutamate receptor activity • cation channel activity • extracellular-glutamate-gated ion channel activity • receptor activity • Ras guanyl-nucleotide exchange factor activity
Cellular component	• integral component of membrane • postsynaptic membrane • membrane • synaptic vesicle • postsynaptic density • plasma membrane • synapse • integral component of plasma membrane • NMDA selective glutamate receptor complex • cell surface • cell junction • endoplasmic reticulum • neuron projection • presynaptic membrane • postsynaptic density membrane • integral component of postsynaptic density membrane
Biological process	• visual learning • protein localization • glutamate receptor signaling pathway • neurogenesis • startle response • regulation of sensory perception of pain • positive regulation of long-term synaptic potentiation • negative regulation of protein catabolic process • response to amphetamine • regulation of membrane potential • directional locomotion • modulation of synaptic transmission • memory • serotonin metabolic process • ion transport • learning • cation transmembrane transport • MAPK cascade • regulation of synaptic plasticity • sleep • dopamine metabolic process • ionotropic glutamate receptor signaling pathway • response to wounding • calcium ion transmembrane transport • locomotion • regulation of postsynaptic membrane potential • excitatory postsynaptic potential • transport • learning or memory • positive regulation of apoptotic process • sensory perception of pain • response to ethanol • response to drug • calcium ion transport • long-term synaptic potentiation • chemical synaptic transmission • positive regulation of GTPase activity • ion transmembrane transport • regulation of ion transmembrane transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2903


14811

Ensembl


ENSG00000183454


ENSMUSG00000059003

UniProt


Q12879


P35436

RefSeq (mRNA)


NM_000833 NM_001134407 NM_001134408


NM_008170

RefSeq (protein)


NP_000824 NP_001127879 NP_001127880


NP_032196.2 NP_032196

Location (UCSC)

Chr 16: 9.75 – 10.18 Mb

Chr 16: 9.57 – 10 Mb

PubMed search

3NFL, 5H8Q, 5H8H, 5H8N, 5H8F, 5I2N, 5I2K, 5KDT, 5KCJ

NM_000833
NM_001134407
NM_001134408

NM_008170

NP_000824
NP_001127879
NP_001127880

...
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