Muscarinic acetylcholine receptor M3

CHRM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CSA
Identifiers
Aliases	CHRM3, EGBRS, HM3, PBS, cholinergic receptor muscarinic 3
External IDs	MGI: 88398 HomoloGene: 20191 GeneCards: CHRM3
Genetically Related Diseases
epilepsy
Targeted by Drug
acetylcholine, arecoline, bethanechol, milameline, pilocarpine, sabcomeline, xanomeline, brucine, vinburnine, vincamine, aclidinium, AFDX384, amitriptyline, biperiden, clidinium, darifenacin, dicyclomine, glycopyrrolate, hexocyclium, himbacine, methoctramine free base, oxybutynin, pirenzepine, propantheline, 3-quinuclidinyl-benzilate, tolterodine, tropicamide, , oxotremorine
Gene ontology Molecular function • G-protein coupled receptor activity • acetylcholine binding • signal transducer activity • protein binding • drug binding • phosphatidylinositol phospholipase C activity • receptor activity • G-protein coupled acetylcholine receptor activity Cellular component • axon terminus • integral component of membrane • postsynaptic membrane • membrane • synapse • integral component of plasma membrane • cell junction • basolateral plasma membrane • dendrite • asymmetric synapse • plasma membrane Biological process • smooth muscle contraction • G-protein coupled acetylcholine receptor signaling pathway • G-protein coupled receptor signaling pathway • digestion • synaptic transmission, cholinergic • saliva secretion • nervous system development • cellular protein modification process • adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway • regulation of vasoconstriction • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway • cell proliferation • positive regulation of smooth muscle contraction • regulation of vascular smooth muscle contraction • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1131	12671
Ensembl	ENSG00000133019	ENSMUSG00000046159
UniProt	P20309	Q9ERZ3
RefSeq (mRNA)	NM_000740 NM_001347716	NM_033269
RefSeq (protein)	NP_000731 NP_001334645	NP_150372.1 NP_150372
Location (UCSC)	Chr 1: 239.39 – 239.92 Mb	Chr 13: 9.88 – 10.36 Mb
PubMed search

2CSA

1131

12671

ENSG00000133019

ENSMUSG00000046159

P20309

Q9ERZ3

NM_000740
NM_001347716

NM_033269

NP_000731
NP_001334645

NP_150372.1
NP_150372

The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M₃, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.

The M₃ muscarinic receptors are located at many places in the body, e.g., smooth muscles, the endocrine glands, the exocrine glands, lungs, pancreas and the brain. In the CNS, they induce emesis. Muscarinic M₃ receptors are expressed in regions of the brain that regulate insulin homeostasis, such as the hypothalamus and dorsal vagal complex of the brainstem. These receptors are highly expressed on pancreatic beta cells and are critical regulators of glucose homoestasis by modulating insulin secretion. In general, they cause smooth muscle contraction and increased glandular secretions.

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Wikipedia