Dicycloverine

Dicycloverine

Clinical data
Trade names	Byclomine, Bentyl, Dibent, Di-Spaz, Dilomine
AHFS/Drugs.com	International Drug Names
MedlinePlus	a684007
Pregnancy category	AU: B1 US: B (No risk in non-human studies)
ATC code	A03AA07 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	>99%
Biological half-life	5 h
Identifiers
IUPAC name 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
CAS Number	77-19-0 Y
PubChem CID	3042
IUPHAR/BPS	355
DrugBank	DB00804 Y
ChemSpider	2934 Y
UNII	4KV4X8IF6V
KEGG	D07820 Y
ChEBI	CHEBI:4514 Y
ChEMBL	CHEMBL1123 Y
ECHA InfoCard	100.000.919
Chemical and physical data
Formula	C19H35NO2
Molar mass	309.487 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(OCCN(CC)CC)C1(CCCCC1)C2CCCCC2
InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3 Y Key:CURUTKGFNZGFSE-UHFFFAOYSA-N Y

Dicycloverine, also known as dicyclomine, is a prescription medication that relieves muscle spasms in the gastrointestinal tract through an apparent mechanism of nonselective smooth muscle relaxation, and that presents a range of anticholinergic side effects. It was first synthesized in the United States circa 1947.

Dicyclomine is used to treat intestinal hypermotility, and the symptoms of irritable bowel syndrome (also known as spastic colon). It relieves muscle spasms in the gastrointestinal tract; while the mechanism or mechanisms of dicycloverine action were, as of 2004, unestablished, the drug "appears to act as nonselective smooth muscle relaxant." The drug presents adverse events that are "manifestations of pharmacologic effects at muscarinic-cholinergic receptors," events which are "usually... reversible when therapy is discontinued."

In the UK, it is an ingredient of a multiple-ingredient preparation, with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon. In India, it is of a compound with paracetamol under the trade name Cyclopam. It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic. Also it is a part of Normaxin containing two other salts clidinium bromide and chlordiazepoxide.

Dicycloverine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects. Recreational use of this drug for its anticholinergic effects (both low dose for euphoria and high dose for delirium) has been rarely reported.