Biperiden

Biperiden
Clinical data


AHFS/Drugs.com	Monograph
MedlinePlus	a699058
Pregnancy category	AU: B2 US: C (Risk not ruled out)
Routes of administration	by mouth, IM, IV
ATC code	N04AA02 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	33 ± 5% (by mouth)
Protein binding	60%
Metabolism	Liver hydroxylation
Biological half-life	18 to 24 hours
Excretion	Kidney
Identifiers
IUPAC name (1RS,2SR,4RS)-1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin- 1-yl)propan-1-ol
CAS Number	514-65-8^Y
PubChem CID	2381
IUPHAR/BPS	7128
DrugBank	DB00810^Y
ChemSpider	2289^Y
UNII	0FRP6G56LD
KEGG	D00779^Y
ChEBI	CHEBI:3112^Y
ChEMBL	CHEMBL1101^Y
ECHA InfoCard	100.007.441
Chemical and physical data
Formula	C₂₁H₂₉NO
Molar mass	311.461 g/mol
3D model (Jmol)	Interactive image
SMILES OC(c1ccccc1)(CCN2CCCCC2)C4C3\C=C/C(C3)C4
InChI InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2^Y Key:YSXKPIUOCJLQIE-UHFFFAOYSA-N^Y

Biperiden, sold under the brandname Akineton among others, is a medication used to treat Parkinson disease and certain drug-induced movement disorders. It is not recommended for tardive dyskinesias. It is taken by mouth, injection into a vein, or muscle.

Common side effects include blurred vision, dry mouth, sleepiness, constipation, and confusion. It should not be used in people with a bowel obstruction or glaucoma. It is unclear if use in pregnancy or breastfeeding is safe. Biperiden is in the anticholinergic family of medication.

Biperiden was approved for medical use in the United States in 1959. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 1.52 to 12.92 USD per month. In the United States it costs about 50 to 100 USD per month.

Biperiden is used for the adjunctive treatment of all forms of Parkinson's disease and for reduced sweating in methadone users (postencephalitic, idiopathic, and arteriosclerotic). It seems to exert better effects in the postencephalitic and idiopathic than in the arteriosclerotic type.

Biperiden is also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy, such as akathisia.

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Wikipedia