Muscarinic acetylcholine receptor M1

CHRM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CXV
Identifiers
Aliases	CHRM1, HM1, M1, M1R, cholinergic receptor muscarinic 1
External IDs	MGI: 88396 HomoloGene: 20189 GeneCards: CHRM1
Targeted by Drug
acetylcholine, arecoline, bethanechol, milameline, pilocarpine, sabcomeline, xanomeline, brucine, vinburnine, vincamine, clozapine, norclozapine, staurosporine, aclidinium, AFDX384, amitriptyline, biperiden, darifenacin, dicyclomine, glycopyrrolate, himbacine, methoctramine free base, oxybutynin, pirenzepine, propantheline, 3-quinuclidinyl-benzilate, tolterodine, trihexyphenidyl, , oxotremorine
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • drug binding • phosphatidylinositol phospholipase C activity • G-protein coupled acetylcholine receptor activity Cellular component • axon terminus • integral component of membrane • postsynaptic membrane • membrane • postsynaptic density • plasma membrane • integral component of plasma membrane • cell junction • dendrite • asymmetric synapse • synapse Biological process • positive regulation of intracellular protein transport • G-protein coupled receptor signaling pathway • cognition • regulation of locomotion • synaptic transmission, cholinergic • saliva secretion • nervous system development • neuromuscular synaptic transmission • protein kinase C-activating G-protein coupled receptor signaling pathway • cellular protein modification process • adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway • positive regulation of ion transport • positive regulation of cell proliferation • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway • cell proliferation • regulation of vascular smooth muscle contraction • signal transduction • G-protein coupled acetylcholine receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1128	12669
Ensembl	ENSG00000168539	ENSMUSG00000032773
UniProt	P11229	P12657
RefSeq (mRNA)	NM_000738	NM_001112697 NM_007698
RefSeq (protein)	NP_000729	NP_001106167.1 NP_031724.2 NP_001106167 NP_031724
Location (UCSC)	Chr 11: 62.91 – 62.92 Mb	Chr 19: 8.66 – 8.68 Mb
PubMed search

5CXV

1128

12669

ENSG00000168539

ENSMUSG00000032773

P11229

P12657

NM_000738

NM_001112697
NM_007698

NP_000729

NP_001106167.1
NP_031724.2
NP_001106167
NP_031724

The muscarinic acetylcholine receptor M₁, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene. It is localized to 11q13.

This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve, is common in exocrine glands and in the CNS.

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Wikipedia