Glucocorticoid receptor

NR3C1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M2Z, 1NHZ, 1P93, 3BQD, 3CLD, 3E7C, 3H52, 3K22, 3K23, 4CSJ, 4HN5, 4HN6, 4LSJ, 4MDD, 4P6W, 4P6X, 5CBY, 5CBX, 4UDC, 4UDD, 5CBZ, 5CC1, 5EMQ, 5EMC, 5EMP
Identifiers
Aliases	NR3C1, GCCR, GCR, GCRST, GR, GRL, nuclear receptor subfamily 3 group C member 1, Glucocorticoid Receptor
External IDs	MGI: 95824 HomoloGene: 30960 GeneCards: NR3C1
Targeted by Drug
budesonide, ciclesonide, clobetasol propionate, hydrocortisone, desoxycortone, desoximetasone, dexamethasone, difluprednate, fluocinolone acetonide, fluocinonide, fluorometholone, fluticasone, fluticasone propionate, methylprednisolone, prednisolone, prednisone, RU28362, triamcinolone, triamcinolone acetonide, betamethasone, mifepristone
Gene ontology Molecular function • steroid hormone binding • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • glucocorticoid receptor activity • glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • steroid hormone receptor activity • steroid binding • protein binding • lipid binding • RNA binding Cellular component • cytoplasm • nucleoplasm • mitochondrial matrix • mitochondrion • nucleus • cytoskeleton • spindle • microtubule organizing center • cytosol • protein complex Biological process • cellular response to steroid hormone stimulus • regulation of transcription, DNA-templated • glucocorticoid mediated signaling pathway • transcription from RNA polymerase II promoter • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • glucocorticoid receptor signaling pathway • signal transduction • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway • mitotic nuclear division • cell cycle • cell division • apoptotic process • chromosome segregation • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2908	14815
Ensembl	ENSG00000113580	ENSMUSG00000024431
UniProt	P04150 Q3MSN4	P06537
RefSeq (mRNA)	NM_000176 NM_001018074 NM_001018075 NM_001018076 NM_001018077 NM_001020825 NM_001024094 NM_001204258 NM_001204259 NM_001204260 NM_001204261 NM_001204262 NM_001204263 NM_001204264 NM_001204265	NM_008173
RefSeq (protein)	NP_000167 NP_001018084 NP_001018085 NP_001018086 NP_001018087 NP_001018661 NP_001019265 NP_001191187 NP_001191188 NP_001191189 NP_001191190 NP_001191191 NP_001191192 NP_001191193 NP_001191194 NP_000167.1 NP_001018084.1 NP_001018085.1 NP_001018086.1 NP_001018087.1 NP_001018661.1 NP_001019265.1 NP_001191187.1 NP_001191188.1 NP_001191189.1 NP_001191190.1 NP_001191191.1 NP_001191192.1 NP_001191193.1	n/a
Location (UCSC)	Chr 5: 143.28 – 143.44 Mb	Chr 18: 39.41 – 39.49 Mb
PubMed search

1M2Z, 1NHZ, 1P93, 3BQD, 3CLD, 3E7C, 3H52, 3K22, 3K23, 4CSJ, 4HN5, 4HN6, 4LSJ, 4MDD, 4P6W, 4P6X, 5CBY, 5CBX, 4UDC, 4UDD, 5CBZ, 5CC1, 5EMQ, 5EMC, 5EMP

2908

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