Prednisolone

Prednisolone

Clinical data
Trade names	many
AHFS/Drugs.com	Monograph
MedlinePlus	a682794
License data	US FDA: prednisolone
Pregnancy category	AU: A US: C (Risk not ruled out)
ATC code	A07EA01 (WHO) C05AA04 (WHO), D07AA03 (WHO), H02AB06 (WHO), R01AD02 (WHO), S01BA04 (WHO), S02BA03 (WHO), S03BA02 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Biological half-life	2-3 hours
Excretion	urine
Identifiers
IUPAC name (11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
Synonyms	11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a] phenanthren-3-one
CAS Number	50-24-8 Y
PubChem CID	5755
IUPHAR/BPS	2866
DrugBank	DB00860 Y
ChemSpider	5552 Y
UNII	9PHQ9Y1OLM
KEGG	D00472 Y
ChEBI	CHEBI:8378 Y
ChEMBL	CHEMBL131 Y
ECHA InfoCard	100.000.020
Chemical and physical data
Formula	C21H28O5
Molar mass	360.444 g/mol
3D model (Jmol)	Interactive image
SMILES O=C\1\C=C/[C@]4(/C(=C/1)CC[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)CC[C@@H]23)C)C
InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 Y Key:OIGNJSKKLXVSLS-VWUMJDOOSA-N Y

Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers. Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, and multiple sclerosis. It is used by mouth, injection into a vein, as a skin cream, and as eye drops.

Side effects with short term use include nausea and feeling tired. More severe side effects include pyschiatric problems, which may occur in about 5% of people. Common side effects with long term use include bone loss, weakness, yeast infections, and easy bruising. While short term use in the later part of pregnancy is safe, use long term or early in early pregnancy is occasionally associated with harm to the baby. It is a glucocorticoid made from hydrocortisone (cortisol).

Prednisolone was discovered and approved for medical use in 1955. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is about 0.01 to 0.02 USD per day.