Prednisone

Prednisone

Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a601102
Pregnancy category	C
Routes of administration	Oral, Nasal, Rectal, Injection, IV
ATC code	A07EA03 (WHO) H02AB07 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	70%
Metabolism	prednisolone (liver)
Biological half-life	18 to 36 hours.
Excretion	Renal
Identifiers
IUPAC name 17,21-dihydroxypregna-1,4-diene-3,11,20-trione
Synonyms	Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone, Prednisonum
CAS Number	53-03-2 Y
PubChem CID	5865
IUPHAR/BPS	7096
DrugBank	DB00635 Y
ChemSpider	5656 Y
UNII	VB0R961HZT
KEGG	C07370 Y
ChEBI	CHEBI:8382 Y
ChEMBL	CHEMBL635 Y
ECHA InfoCard	100.000.147
Chemical and physical data
Formula	C21H26O5
Molar mass	358.428 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)\C=C/[C@]1(C)[C@H]4C(=O)C[C@@]23C
InChI InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 Y Key:XOFYZVNMUHMLCC-ZPOLXVRWSA-N Y
NY (what is this?)

Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases (such as moderate allergic reactions), some autoimmune diseases, and (at higher doses) some types of cancer, but it has significant adverse effects.

Prednisone is used, at a usual adult dosage of 5–60 mg/day, for many different indications including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, and as part of a drug regimen to prevent rejection after organ transplant.