Fluorometholone

Fluorometholone

Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a682660
Pregnancy category	C
ATC code	C05AA06 (WHO) D07AB06 (WHO), D07XB04 (WHO) (combinations), D10AA01 (WHO), S01BA07 (WHO)
Identifiers
IUPAC name (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Synonyms	(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number	426-13-1 Y
PubChem CID	9878
IUPHAR/BPS	7079
DrugBank	DB00324 Y
ChemSpider	9494 Y
UNII	SV0CSG527L
KEGG	D01367 Y
ChEBI	CHEBI:31625 N
ChEMBL	CHEMBL1200600 N
ECHA InfoCard	100.006.402
Chemical and physical data
Formula	C22H29FO4
Molar mass	376.462 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C
InChI InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 Y Key:FAOZLTXFLGPHNG-KNAQIMQKSA-N Y
NY (what is this?)

Fluorometholone (INN, BAN, JAN) (brand names Efflumidex, Flucon, FML Forte, FML, others), also known as 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases. The C17α acetate ester, fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications. Specifically, it is indicated for use in the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

Most common indication for this drug is seasonal allergic conjunctivitis and other allergies of the eye.