Fursultiamine

Fursultiamine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	None
Legal status
Legal status	In general: Over-the-counter (OTC)
Identifiers
IUPAC name N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-{(1E)-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
CAS Number	804-30-8
PubChem CID	3002119
DrugBank	DB08966 N
ChemSpider	2273321
UNII	05J61265PX
ChEMBL	CHEMBL1740659
ECHA InfoCard	100.011.234
Chemical and physical data
Formula	C17H26N4O3S2
Molar mass	398.54 g/mol
3D model (Jmol)	Interactive image
SMILES O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C

Fursultiamine (INN; Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor), also known as thiamine tetrahydrofurfuryl disulfide (TTFD), is a disulfide derivative of thiamine, or an allithiamine. It was synthesized in Japan in the 1960s for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B₁ deficiency (i.e., beriberi), and was subsequently commercialized not only in Japan but also in Spain, Austria, Germany, and the United States. As a vitamin, it is available over-the-counter as well.

In addition to its clinical indication of avitaminosis, fursultiamine has been studied in clinical trials for Alzheimer's disease and autistic spectrum disorders with positive but modest benefits. It has also been investigated in improving energy metabolism during exercise and reducing exercise-induced fatigue with conflicting results.

Available Brands: Privitamix softgel (India)