Estrogen receptor beta

ESR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J26, 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4ZI1
Identifiers
Aliases	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, estrogen receptor 2
External IDs	OMIM: 601663 MGI: 109392 HomoloGene: 1100 GeneCards: ESR2
Targeted by Drug
17β-estradiol, diethylstilbestrol, estriol, estrone, ethinylestradiol, genistein, tamoxifen, bisphenol A, lasofoxifene, bazedoxifene, raloxifene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • estrogen receptor activity • metal ion binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding • steroid binding • zinc ion binding • protein binding • DNA binding • sequence-specific DNA binding • transcription coactivator activity • receptor antagonist activity • lipid binding • enzyme binding • estrogen response element binding • core promoter sequence-specific DNA binding Cellular component • mitochondrion • nucleus • nucleoplasm • extracellular region Biological process • intracellular estrogen receptor signaling pathway • steroid hormone mediated signaling pathway • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of cell growth • transcription initiation from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • cell-cell signaling • signal transduction • extracellular negative regulation of signal transduction • positive regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2100	13983
Ensembl	ENSG00000140009	ENSMUSG00000021055
UniProt	Q92731	O08537
RefSeq (mRNA)	NM_001040275 NM_001040276 NM_001214902 NM_001214903 NM_001271876 NM_001271877 NM_001291712 NM_001291723 NM_001437	NM_010157 NM_207707
RefSeq (protein)	NP_001035365 NP_001201831 NP_001258805 NP_001258806 NP_001278641 NP_001278652 NP_001428	NP_034287.3 NP_997590.1 NP_034287 NP_997590
Location (UCSC)	Chr 14: 64.08 – 64.34 Mb	Chr 12: 76.12 – 76.18 Mb
PubMed search

4J26, 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4ZI1

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