Cystic fibrosis transmembrane conductance regulator

CFTR

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1XMI, 1XMJ, 2BBO, 2BBS, 2BBT, 2LOB, 2PZE, 2PZF, 2PZG, 3GD7, 3ISW, 4WZ6, 5D2D, 5D3E, 5D3F

Identifiers

Aliases

CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-dJ760C5.1, cystic fibrosis transmembrane conductance regulator

External IDs

OMIM: 602421 MGI: 88388 HomoloGene: 55465 GeneCards: CFTR

EC number

3.6.3.49

Targeted by Drug

apigenin, capsaicin, felodipine, genistein, ivacaftor, nimodipine, glyburide

Gene ontology
Molecular function	• nucleotide binding • PDZ domain binding • chloride transmembrane transporter activity • bicarbonate transmembrane transporter activity • protein binding • chloride channel inhibitor activity • enzyme binding • hydrolase activity • ATP binding • chloride channel activity • ATPase-coupled anion transmembrane transporter activity • chloride channel regulator activity • ATPase activity, coupled to transmembrane movement of substances • intracellular ATPase-gated chloride channel activity • ATPase activity
Cellular component	• cytoplasm • recycling endosome • endosome • early endosome membrane • membrane • plasma membrane • chloride channel complex • protein complex • cell surface • lysosomal membrane • early endosome • apical plasma membrane • Golgi-associated vesicle membrane • endoplasmic reticulum Sec complex • extracellular exosome • cytosol • endosome membrane • clathrin-coated vesicle membrane • endoplasmic reticulum membrane • integral component of plasma membrane • integral component of membrane
Biological process	• positive regulation of cyclic nucleotide-gated ion channel activity • intracellular pH elevation • membrane hyperpolarization • positive regulation of voltage-gated chloride channel activity • cholesterol transport • ion transport • vesicle docking involved in exocytosis • transmembrane transport • transport • sperm capacitation • positive regulation of insulin secretion involved in cellular response to glucose stimulus • cholesterol biosynthetic process • positive regulation of exocytosis • chloride transport • cellular response to cAMP • protein deubiquitination • membrane organization • ATP hydrolysis coupled anion transmembrane transport • bicarbonate transport • chloride transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1080


12638

Ensembl


ENSG00000001626


ENSMUSG00000041301

UniProt


P13569


P26361

RefSeq (mRNA)


NM_000492


NM_021050

RefSeq (protein)


NP_000483


NP_066388.1 NP_066388

Location (UCSC)

Chr 7: 117.47 – 117.72 Mb

Chr 6: 18.17 – 18.32 Mb

PubMed search

1XMI, 1XMJ, 2BBO, 2BBS, 2BBT, 2LOB, 2PZE, 2PZF, 2PZG, 3GD7, 3ISW, 4WZ6, 5D2D, 5D3E, 5D3F

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