CRTH2

PTGDR2
Identifiers
Aliases	PTGDR2, CD294, CRTH2, DL1R, DP2, GPR44, prostaglandin D2 receptor 2
External IDs	MGI: 1330275 HomoloGene: 3508 GeneCards: PTGDR2
Gene ontology Molecular function • prostaglandin D receptor activity • G-protein coupled receptor activity • prostaglandin J receptor activity • prostaglandin F receptor activity • neuropeptide binding • signal transducer activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • neuron projection • intracellular Biological process • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • chemotaxis • positive regulation of G-protein coupled receptor protein signaling pathway • immune response • neuropeptide signaling pathway • calcium-mediated signaling • negative regulation of male germ cell proliferation • signal transduction • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11251	14764
Ensembl	ENSG00000183134	ENSMUSG00000034117
UniProt	Q9Y5Y4	Q9Z2J6
RefSeq (mRNA)	NM_004778	NM_009962
RefSeq (protein)	NP_004769	NP_034092
Location (UCSC)	Chr 11: 60.85 – 60.86 Mb	Chr 19: 10.94 – 10.94 Mb
PubMed search

11251

14764

ENSG00000183134

ENSMUSG00000034117

Q9Y5Y4

Q9Z2J6

NM_004778

NM_009962

NP_004769

NP_034092

Prostaglandin D₂ receptor 2 (DP₂ or CRTH2) is a human protein encoded by the PTGDR2 gene and GPR44. DP₂ has also been designated as CD294 (cluster of differentiation 294). It is a member of the class of prostaglandin receptors which bind with and respond to various prostaglandins. DP₂ along with Prostaglandin DP1 receptor are receptors for prostaglandin D2 (PGD2). Activation of DP₂ by PGD2 or other cognate receptor ligands has been associated with certain physiological and pathological responses, particularly those associated with allergy and inflammation, in animal models and certain human diseases.

The PTGDR2 gene is located on human chromosome 11 at position q12.2 (i.e. 11q12.2). It consists of two introns and three exons and codes for a G protein coupled receptor (GPCR) composed of 472 amino acids. DP₂, is related to members of the chemotactic factor class of GPCRs, sharing an amino acid sequence identity of 29% with the C5a receptor, Formyl peptide receptor 1, and Formyl peptide receptor 2 receptors. DP₂ has little or no such amino acid sequence relationship to the eight other Prostanoid receptors (see Eicosanoid receptor#Prostenoid receptors).

...
Wikipedia