Formyl peptide receptor 1

FPR1
Identifiers
Aliases	FPR1, FMLP, FPR, formyl peptide receptor 1
External IDs	MGI: 107443 HomoloGene: 20466 GeneCards: FPR1
Targeted by Drug
fMet-Leu-Phe, chenodiol, cyclosporine, deoxycholic acid, spinorphin, sulfinpyrazone
Gene ontology Molecular function • RAGE receptor binding • signal transducer activity • G-protein coupled receptor activity • protein binding • N-formyl peptide receptor activity • complement receptor activity Cellular component • plasma membrane • membrane • integral component of membrane • integral component of plasma membrane • secretory granule membrane • azurophil granule membrane • ficolin-1-rich granule membrane Biological process • activation of MAPK activity • phospholipase C-activating G-protein coupled receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • nitric oxide mediated signal transduction • G-protein coupled receptor signaling pathway • signal transduction • chemotaxis • complement receptor mediated signaling pathway • inflammatory response • positive regulation of cytosolic calcium ion concentration • neutrophil degranulation • leukocyte migration • cell chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2357	14293
Ensembl	ENSG00000171051	ENSMUSG00000045551
UniProt	P21462	P33766
RefSeq (mRNA)	NM_002029 NM_001193306	NM_013521
RefSeq (protein)	NP_001180235 NP_002020	NP_038549.1 NP_038549
Location (UCSC)	Chr 19: 51.75 – 51.8 Mb	Chr 17: 17.88 – 17.88 Mb
PubMed search

2357

14293

ENSG00000171051

ENSMUSG00000045551

P21462

P33766

NM_002029
NM_001193306

NM_013521

NP_001180235
NP_002020

NP_038549.1
NP_038549

Formyl peptide receptor 1 (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl-phenylalanine receptor 1) is a cell surface receptor protein that in humans is encoded by the formyl peptide receptor 1 (FPR1) gene. This gene encodes a G protein-coupled receptor cell surface protein that binds and is activated by N-Formylmethionine-containing oligopeptides, particularly N-Formylmethionine-leucyl-phenylalanine (FMLP). FPR1 is prominently expressed by mammalian phagocytic and blood leukocyte cells where it functions to mediate these cells' responses to the N-formylmethionine-containing oligopeptides which are released by invading microorganisms and injured tissues. FPR1 directs these cells to sites of invading pathogens or disrupted tissues and then stimulates these cells to kill the pathogens or to remove tissue debris; as such, it is an important component of the innate immune system that operates in host defense and damage control.

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