Formyl peptide receptor 2

FPR2
Identifiers
Aliases	FPR2, ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R, formyl peptide receptor 2
External IDs	MGI: 1278319 HomoloGene: 74395 GeneCards: FPR2
Gene location (Human) Chr. Chromosome 19 (human) Band No data available Start 51,752,026 bp End 51,770,526 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band No data available Start 17,887,824 bp End 17,893,952 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • G-protein coupled receptor activity • complement receptor activity • N-formyl peptide receptor activity Cellular component • plasma membrane • membrane • integral component of membrane • integral component of plasma membrane • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane Biological process • movement of cell or subcellular component • inflammatory response • signal transduction • cell adhesion • chemotaxis • G-protein coupled receptor signaling pathway • complement receptor mediated signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • neutrophil degranulation • leukocyte migration • cell chemotaxis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2358	14289
Ensembl	ENSG00000171049	ENSMUSG00000052270
UniProt	P25090	O88536
RefSeq (mRNA)	NM_001005738 NM_001462	NM_008039
RefSeq (protein)	NP_001005738 NP_001453	NP_032065
Location (UCSC)	Chr 19: 51.75 – 51.77 Mb	Chr 17: 17.89 – 17.89 Mb
PubMed search

2358

14289

ENSG00000171049

ENSMUSG00000052270

P25090

O88536

NM_001005738
NM_001462

NM_008039

NP_001005738
NP_001453

NP_032065

N-formyl peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species. The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides such as N-Formylmethionine-leucyl-phenylalanine (FMLP) but also the polyunsaturated fatty acid metabolite of arachidonic acid, lipoxin A4 (LXA4). Because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor.

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Wikipedia