C5a receptor

C5AR1
Identifiers
Aliases	C5AR1, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor
External IDs	MGI: 88232 HomoloGene: 20413 GeneCards: C5AR1
Gene ontology Molecular function • complement component C5a binding • signal transducer activity • complement receptor activity • complement component C5a receptor activity • G-protein coupled receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • apical part of cell • integral component of plasma membrane • cell surface • basolateral plasma membrane • cytoplasmic vesicle • secretory granule membrane Biological process • negative regulation of neuron apoptotic process • G-protein coupled receptor signaling pathway • positive regulation of epithelial cell proliferation • mRNA transcription from RNA polymerase II promoter • activation of phospholipase C activity • neutrophil chemotaxis • positive regulation of angiogenesis • chemotaxis • cellular defense response • response to lipopolysaccharide • activation of MAPK activity • animal organ regeneration • immune response • response to peptidoglycan • positive regulation of ERK1 and ERK2 cascade • positive regulation of neutrophil chemotaxis • complement receptor mediated signaling pathway • sensory perception of chemical stimulus • positive regulation of vascular endothelial growth factor production • cell proliferation in hindbrain • positive regulation of macrophage chemotaxis • signal transduction • defense response to Gram-positive bacterium • apoptotic process • complement component C5a signaling pathway • regulation of complement activation • inflammatory response • phospholipase C-activating G-protein coupled receptor signaling pathway • neutrophil degranulation • leukocyte migration • cell chemotaxis • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	728	12273
Ensembl	ENSG00000197405	ENSMUSG00000049130
UniProt	P21730	P30993
RefSeq (mRNA)	NM_001736	NM_001173550 NM_007577
RefSeq (protein)	NP_001727	NP_001167021.1 NP_031603.2 NP_001167021 NP_031603
Location (UCSC)	Chr 19: 47.29 – 47.32 Mb	Chr 7: 16.25 – 16.26 Mb
PubMed search

728

12273

ENSG00000197405

ENSMUSG00000049130

P21730

P30993

NM_001736

NM_001173550
NM_007577

NP_001727

NP_001167021.1
NP_031603.2
NP_001167021
NP_031603

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor. C5a receptor modulates inflammatory responses, obesity, development and cancers.

The C5a receptor is expressed on:

Potent and selective agonist and antagonists for C5aR have been developed.

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Wikipedia