Prostaglandin DP1 receptor

PTGDR
Identifiers
Aliases	PTGDR, AS1, ASRT1, DP, DP1, PTGDR1, prostaglandin D2 receptor (DP)
External IDs	OMIM: 604687 MGI: 102966 HomoloGene: 736 GeneCards: PTGDR
Targeted by Drug
prostaglandin D2, alprostadil, dinoprostone, dinoprost, treprostinil, U46619
Gene ontology Molecular function • protein binding • signal transducer activity • G-protein coupled receptor activity • prostaglandin J receptor activity • prostaglandin D receptor activity • prostaglandin E receptor activity Cellular component • integral component of membrane • plasma membrane • membrane Biological process • sleep • adenosine metabolic process • G-protein coupled receptor signaling pathway • signal transduction • male sex determination • positive regulation of vasodilation • inflammatory response • cellular response to prostaglandin E stimulus • cellular response to prostaglandin D stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5729	19214
Ensembl	ENSG00000168229	ENSMUSG00000071489
UniProt	Q13258	P70263
RefSeq (mRNA)	NM_000953 NM_001281469	NM_008962
RefSeq (protein)	NP_000944 NP_001268398	NP_032988.3 NP_032988
Location (UCSC)	Chr 14: 52.27 – 52.28 Mb	Chr 14: 44.85 – 44.86 Mb
PubMed search

5729

19214

ENSG00000168229

ENSMUSG00000071489

Q13258

P70263

NM_000953
NM_001281469

NM_008962

NP_000944
NP_001268398

NP_032988.3
NP_032988

The Prostaglandin D₂ receptor 1 (DP₁), a G protein-coupled receptor encoded by the PTGDR1 gene (also termed PTGDR), is primarily a receptor for prostaglandin D₂ (PGD₂). The receptor is a member of the Prostaglandin receptors belonging to the Subfamily A14 of rhodopsin-like receptors. Activation of DP1 by PGD2 or other cognate receptor ligands is associated with a variety of physiological and pathological responses in animal models.

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Wikipedia