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Antiandrogens

Antiandrogen
Drug class
Bicalutamide.svg
Bicalutamide, a non-steroidal antiandrogen and the most widely used androgen receptor antagonist in the treatment of prostate cancer.
Class identifiers
Synonyms Androgen antagonists; Androgen blockers; Testosterone blockers
Use Various
ATC code L02BB
Biological target Androgen receptor
Chemical class Steroidal; Non-steroidal
External links
MeSH D000726

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs which prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. They act by blocking the androgen receptor (AR) and/or inhibiting or suppressing androgen production. Antiandrogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiprogestogens.

Antiandrogens are used to treat an assortment of androgen-dependent conditions. In males, antiandrogens are used in the treatment of prostate cancer, benign prostatic hyperplasia, androgenic alopecia (pattern hair loss), hypersexuality, paraphilias, and precocious puberty. In women, antiandrogens are used to treat acne, seborrhea, hidradenitis suppurativa, hirsutism, and hyperandrogenism, such as that which occurs in polycystic ovary syndrome (PCOS). Antiandrogens are also used as a component of hormone replacement therapy (HRT) for transgender women.


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