Activating transcription factor-1

ATF1
Identifiers
Aliases	ATF1, EWS-FUS/ATF-1, TREB36, activating transcription factor 1
External IDs	MGI: 3037720 HomoloGene: 3790 GeneCards: ATF1
Gene location (Human) Chr. Chromosome 12 (human) Band No data available Start 50,763,710 bp End 50,821,122 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • protein complex binding • protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • ATF1-ATF4 transcription factor complex • transcription factor complex • nucleoplasm • nucleus Biological process • regulation of transcription, DNA-templated • response to organic cyclic compound • cellular protein complex assembly • transcription, DNA-templated • positive regulation of DNA replication • positive regulation of neuron projection development • response to cobalt ion • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	466	100040260
Ensembl	ENSG00000123268	n/a
UniProt	P18846	n/a
RefSeq (mRNA)	NM_005171	n/a
RefSeq (protein)	NP_005162	n/a
Location (UCSC)	Chr 12: 50.76 – 50.82 Mb	n/a
PubMed search

466

100040260

ENSG00000123268

n/a

P18846

n/a

NM_005171

n/a

NP_005162

n/a

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

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