Angiomatoid fibrous histiocytoma

Angiomatoid fibrous histiocytoma
Micrograph showing a angiomatoid fibrous histiocytoma. H&E stain.
Classification and external resources
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Angiomatoid fibrous histiocytoma, abbreviated AFH, is a rarely metastasizing tumour that affects children and young adults.

It is characterized cystic blood-filled spaces and composed of histiocyte-like cells. A lymphocytic cuff is common. It often simulates a vascular lesion, and was initially described as doing this.

AFH typically has a chromosomal translocation involving the ATF1 gene -- t(12;16) FUS/ATF1 or t(12;22) EWS/ATF1.

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