*** Welcome to piglix ***

ATF1

ATF1
Protein ATF1 PDB 1dh3.png
Identifiers
Aliases ATF1, EWS-FUS/ATF-1, TREB36, activating transcription factor 1
External IDs MGI: 3037720 HomoloGene: 3790 GeneCards: ATF1
RNA expression pattern
PBB GE ATF1 222103 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005171

XM_001474817
XM_006544560

RefSeq (protein)

NP_005162

n/a

Location (UCSC) Chr 12: 50.76 – 50.82 Mb n/a
PubMed search

NM_005171

XM_001474817
XM_006544560

NP_005162

n/a

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.


...
Wikipedia

...