MAPK13

MAPK13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3COI, 4EYJ, 4EYM, 4MYG, 4YNO, 5EKO, 5EKN
Identifiers
Aliases	MAPK13, MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta, mitogen-activated protein kinase 13
External IDs	MGI: 1346864 HomoloGene: 48133 GeneCards: MAPK13
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding Cellular component • cytosol • nucleus • cytoplasm Biological process • positive regulation of inflammatory response • intracellular signal transduction • regulation of transcription, DNA-templated • phosphorylation • response to stress • transcription, DNA-templated • response to osmotic stress • protein phosphorylation • vascular endothelial growth factor receptor signaling pathway • peptidyl-serine phosphorylation • positive regulation of interleukin-6 production • cell cycle • MAPK cascade • regulation of gene expression Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5603	26415
Ensembl	ENSG00000156711	ENSMUSG00000004864
UniProt	O15264	Q9Z1B7
RefSeq (mRNA)	NM_002754	NM_011950
RefSeq (protein)	NP_002745	NP_036080
Location (UCSC)	Chr 6: 36.13 – 36.14 Mb	Chr 17: 28.77 – 28.78 Mb
PubMed search

3COI, 4EYJ, 4EYM, 4MYG, 4YNO, 5EKO, 5EKN

5603

26415

ENSG00000156711

ENSMUSG00000004864

O15264

Q9Z1B7

NM_002754

NM_011950

NP_002745

NP_036080

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

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Wikipedia