Stathmin

STMN1
Identifiers
Aliases	STMN1, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, stathmin 1
External IDs	OMIM: 151442 MGI: 96739 HomoloGene: 4063 GeneCards: STMN1
Gene ontology Molecular function • protein binding • signal transducer activity • tubulin binding Cellular component • intracellular • cytoplasm • cytoskeleton • microtubule • membrane • cytosol • extracellular exosome • neuron projection Biological process • nervous system development • mitotic spindle organization • multicellular organism development • cell differentiation • positive regulation of cellular component movement • intracellular signal transduction • response to virus • regulation of cytoskeleton organization • axonogenesis • microtubule depolymerization • negative regulation of microtubule polymerization • neuron projection development • regulation of microtubule polymerization or depolymerization • signal transduction • brain development • mitotic cytokinesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3925	16765
Ensembl	ENSG00000117632	ENSMUSG00000028832
UniProt	P16949	P54227
RefSeq (mRNA)	NM_203401 NM_001145454 NM_005563 NM_152497 NM_203399	NM_019641
RefSeq (protein)	NP_001138926 NP_005554 NP_981944 NP_981946	NP_062615.1 NP_062615
Location (UCSC)	Chr 1: 25.88 – 25.91 Mb	Chr 4: 134.47 – 134.47 Mb
PubMed search

Stathmin
Structure of Tubulin-Colchicine-Vinblastine: Stathmin-like domain complex
Identifiers
Symbol	Stathmin
Pfam	PF00836
InterPro	IPR000956
PROSITE	PDOC00487
SCOP	1sa0
SUPERFAMILY	1sa0
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

3925

16765

ENSG00000117632

ENSMUSG00000028832

P16949

P54227

NM_203401
NM_001145454
NM_005563
NM_152497
NM_203399

NM_019641

NP_001138926
NP_005554
NP_981944
NP_981946

NP_062615.1
NP_062615

Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene.

Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell cytoskeleton. Changes in the cytoskeleton are important because the cytoskeleton is a scaffold required for many cellular processes, such as cytoplasmic organization, cell division and cell motility. More specifically, stathmin is crucial in regulating the cell cycle. It is found solely in eukaryotes.