FUS (gene)

FUS
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LA6, 2LCW, 4FDD, 4FQ3
Identifiers
Aliases	FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, FUS RNA binding protein
External IDs	GeneCards: FUS
Gene ontology Molecular function • nucleotide binding • DNA binding • transcription coactivator activity • zinc ion binding • metal ion binding • retinoid X receptor binding • thyroid hormone receptor binding • myosin V binding • protein binding • identical protein binding • nucleic acid binding • ionotropic glutamate receptor binding • estrogen receptor binding • RNA binding Cellular component • cytoplasm • polysome • perikaryon • dendritic spine • nucleoplasm • neuronal cell body • dendrite • dendritic spine head • perinuclear region of cytoplasm • nucleus Biological process • cellular response to calcium ion • mRNA splicing, via spliceosome • regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2521	n/a
Ensembl	ENSG00000089280	n/a
UniProt	P35637	n/a
RefSeq (mRNA)	NM_001010850 NM_001170634 NM_001170937 NM_004960	n/a
RefSeq (protein)	NP_001164105 NP_001164408 NP_004951	n/a
Location (UCSC)	Chr 16: 31.18 – 31.19 Mb	n/a
PubMed search		n/a

2LA6, 2LCW, 4FDD, 4FQ3

2521

n/a

ENSG00000089280

n/a

P35637

n/a

NM_001010850
NM_001170634
NM_001170937
NM_004960

n/a

NP_001164105
NP_001164408
NP_004951

n/a

RNA-binding protein FUS/TLS (Fused in Sarcoma/Translocated in Sarcoma) is a protein that in humans is encoded by the FUS gene.

The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding. In addition recognition sites for the transcription factors AP2, GCF, Sp1 have been identified in FUS.

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