C2orf3

GCFC2
Identifiers
Aliases	GCFC2, C2orf3, DNABF, GCF, TCF9, GC-rich sequence DNA-binding factor 2
External IDs	MGI: 2141656 HomoloGene: 2411 GeneCards: GCFC2
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding Cellular component • nucleolus • nucleus • U2-type post-mRNA release spliceosomal complex • nucleoplasm • cytosol Biological process • mRNA processing • spliceosomal complex assembly • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • RNA splicing • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6936	330361
Ensembl	ENSG00000005436	ENSMUSG00000035125
UniProt	P16383	Q8BKT3
RefSeq (mRNA)	NM_001201334 NM_001201335 NM_003203	NM_177884
RefSeq (protein)	NP_001188263 NP_001188264 NP_003194	NP_808552.2 NP_808552
Location (UCSC)	Chr 2: 75.65 – 75.71 Mb	Chr 6: 81.92 – 81.96 Mb
PubMed search

6936

330361

ENSG00000005436

ENSMUSG00000035125

P16383

Q8BKT3

NM_001201334
NM_001201335
NM_003203

NM_177884

NP_001188263
NP_001188264
NP_003194

NP_808552.2
NP_808552

GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the C2orf3 gene.

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.

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