ARFGEF1

ARFGEF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LTL, 5EE5
Identifiers
Aliases	ARFGEF1, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDs	MGI: 2442988 HomoloGene: 4687 GeneCards: ARFGEF1
Gene location (Human) Chr. Chromosome 8 (human) Band n/a Start 67,173,511 bp End 67,343,677 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band n/a Start 10,137,571 bp End 10,232,670 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • GTPase activator activity • guanyl-nucleotide exchange factor activity • ARF guanyl-nucleotide exchange factor activity • myosin binding • protein binding • protein kinase A regulatory subunit binding Cellular component • cytosol • Golgi apparatus • membrane • nuclear matrix • Golgi membrane • nucleoplasm • trans-Golgi network • nucleolus • small nuclear ribonucleoprotein complex • perinuclear region of cytoplasm • nucleus • cytoplasm Biological process • endomembrane system organization • positive regulation of protein kinase B signaling • negative regulation of actin filament polymerization • Golgi organization • positive regulation of wound healing • regulation of ARF protein signal transduction • positive regulation of protein glycosylation in Golgi • negative regulation of GTPase activity • protein transport • neuron projection development • regulation of establishment of cell polarity • exocytosis • positive regulation of GTPase activity • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10565	211673
Ensembl	ENSG00000066777	ENSMUSG00000067851
UniProt	Q9Y6D6	G3X9K3
RefSeq (mRNA)	NM_006421	NM_001102430
RefSeq (protein)	NP_006412	NP_001095900
Location (UCSC)	Chr 8: 67.17 – 67.34 Mb	Chr 8: 10.14 – 10.23 Mb
PubMed search

3LTL, 5EE5

10565

211673

ENSG00000066777

ENSMUSG00000067851

Q9Y6D6

G3X9K3

NM_006421

NM_001102430

NP_006412

NP_001095900

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.

ARFGEF1 has been shown to interact with FKBP2,ARFGEF2 and PRKAR1A.

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Wikipedia