FKBP2

FKBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PBC, 4NNR
Identifiers
Aliases	FKBP2, FKBP-13, PPIase, FK506 binding protein 2
External IDs	MGI: 95542 HomoloGene: 40604 GeneCards: FKBP2
Gene location (Human) Chr. Chromosome 11 (human) Band No data available Start 64,241,003 bp End 64,244,132 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band No data available Start 6,977,741 bp End 6,980,461 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • FK506 binding • protein binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity Cellular component • extracellular exosome • membrane • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • chaperone-mediated protein folding • protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2286	14227
Ensembl	ENSG00000173486	ENSMUSG00000056629
UniProt	P26885	P45878
RefSeq (mRNA)	NM_001135208 NM_004470 NM_057092	NM_001166368 NM_008020
RefSeq (protein)	NP_001128680 NP_004461 NP_476433	NP_001159840 NP_032046
Location (UCSC)	Chr 11: 64.24 – 64.24 Mb	Chr 11: 6.98 – 6.98 Mb
PubMed search

2PBC, 4NNR

2286

14227

ENSG00000173486

ENSMUSG00000056629

P26885

P45878

NM_001135208
NM_004470
NM_057092

NM_001166368
NM_008020

NP_001128680
NP_004461
NP_476433

NP_001159840
NP_032046

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.

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