ARFGEF2

ARFGEF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L8N, 3SWV
Identifiers
Aliases	ARFGEF2, BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
External IDs	MGI: 2139354 HomoloGene: 111880 GeneCards: ARFGEF2
Gene location (Human) Chr. Chromosome 20 (human) Band n/a Start 48,921,890 bp End 49,036,693 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band n/a Start 166,805,588 bp End 166,898,052 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • GABA receptor binding • ARF guanyl-nucleotide exchange factor activity • myosin binding • protein binding • protein kinase A regulatory subunit binding Cellular component • cytoplasm • recycling endosome • cytosol • endosome • Golgi apparatus • cell projection • membrane • Golgi membrane • dendritic spine • synapse • microtubule organizing center • cell junction • trans-Golgi network • dendrite • symmetric synapse • asymmetric synapse • perinuclear region of cytoplasm • cytoskeleton • cytoplasmic vesicle • axonemal microtubule Biological process • endomembrane system organization • intracellular signal transduction • regulation of ARF protein signal transduction • endosome organization • receptor recycling • positive regulation of tumor necrosis factor production • protein transport • Golgi to plasma membrane transport • exocytosis • positive regulation of GTPase activity • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10564	99371
Ensembl	ENSG00000124198	ENSMUSG00000074582
UniProt	Q9Y6D5	A2A5R2
RefSeq (mRNA)	NM_006420	NM_001085495
RefSeq (protein)	NP_006411	NP_001078964
Location (UCSC)	Chr 20: 48.92 – 49.04 Mb	Chr 20: 166.81 – 166.9 Mb
PubMed search

3L8N, 3SWV

10564

99371

ENSG00000124198

ENSMUSG00000074582

Q9Y6D5

A2A5R2

NM_006420

NM_001085495

NP_006411

NP_001078964

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.

ARFGEF2 has been shown to interact with ARFGEF1,PRKAR1A and PRKAR2A.

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Wikipedia